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Complement Ther Clin Pract. 2018 May;31:170-174. doi: 10.1016/j.ctcp.2018.01.009. Epub 2018 Feb 17.

The barberry juice effects on metabolic factors and oxidative stress in patients with type 2 diabetes: A randomized clinical trial.

Author information

1
Babol University of Medical Sciences, Babol, Iran.
2
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Parvin.Mirmiran@gmail.com.
3
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: golbonsohrab@yahoo.com.
4
Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5
Cellular & Molecular Research Center, Research Institute of Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

AIM:

The aim of this study was to investigate the effect of barberry juice (BJ) on cardiovascular risk factors in patients with type 2 diabetes (T2DM).

METHODS:

46 diabetic Patients were randomly allocated to either the BJ group (n = 23) who consumed 200 ml of BJ daily for eight weeks, or the control group (n = 23) with no intervention. At the baseline and the end of 8-week intervention, blood pressure and biochemical markers were measured.

RESULTS:

forty-two Patients completed the study. After intervention systolic blood pressure (SBP), diastolic blood pressure (DBP), Fasting Blood Sugar (FBS) Total Cholesterol significantly decreased (P < 0.05 for treatment effect) also Triglyceride (TG) decrease significantly in BJ group. Paraoxonase-1(PON1) concentrations significantly increased in Bj group and have a significant difference (P < 0.0001 for treatment effect) compared with control group.

CONCLUSIONS:

This study revealed that BJ might decrease the risk of cardiovascular diseases in patients with diabetes.

KEYWORDS:

Barberry; Metabolic factor; Oxidative stress; Type 2 diabetes

PMID:
29705451
DOI:
10.1016/j.ctcp.2018.01.009
[Indexed for MEDLINE]

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