Format

Send to

Choose Destination
Biosens Bioelectron. 2018 Jul 30;112:162-169. doi: 10.1016/j.bios.2018.04.040. Epub 2018 Apr 18.

Geometric screening of core/shell hydrogel microcapsules using a tapered microchannel with interdigitated electrodes.

Author information

1
Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, United States; Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210, United States.
2
Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, United States.
3
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, United States.
4
Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, United States. Electronic address: zhao.178@osu.edu.

Abstract

Core/shell hydrogel microcapsules attract increasing research attention due to their potentials in tissue engineering, food engineering, and drug delivery. Current approaches for generating core/shell hydrogel microcapsules suffer from large geometric variations. Geometrically defective core/shell microcapsules need to be removed before further use. High-throughput geometric characterization of such core/shell microcapsules is therefore necessary. In this work, a continuous-flow device was developed to measure the geometric properties of microcapsules with a hydrogel shell and an aqueous core. The microcapsules were pumped through a tapered microchannel patterned with an array of interdigitated microelectrodes. The geometric parameters (the shell thickness and the diameter) were derived from the displacement profiles of the microcapsules. The results show that this approach can successfully distinguish all unencapsulated microparticles. The geometric properties of core/shell microcapsules can be determined with high accuracy. The efficacy of this method was demonstrated through a drug releasing experiment where the optimization of the electrospray process based on geometric screening can lead to controlled and extended drug releasing profiles. This method does not require high-speed optical systems, simplifying the system configuration and making it an indeed miniaturized device. The throughput of up to 584 microcapsules per minute was achieved. This study provides a powerful tool for screening core/shell hydrogel microcapsules and is expected to facilitate the applications of these microcapsules in various fields.

KEYWORDS:

Continuous-flow measurement; Core/shell microcapsules; Hydrogel; Microelectrodes array

PMID:
29704784
DOI:
10.1016/j.bios.2018.04.040
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center