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Parkinsonism Relat Disord. 2018 Sep;54:74-78. doi: 10.1016/j.parkreldis.2018.04.021. Epub 2018 Apr 18.

Comparison of two motor subtype classifications in de novo Parkinson's disease.

Author information

1
Department of Neurology, Chonnam National University Hospital, Gwangju, South Korea; National Research Center for Dementia, Gwangju, South Korea.
2
Department of Neurology, Chonnam National University Hospital, Gwangju, South Korea; National Research Center for Dementia, Gwangju, South Korea. Electronic address: byeong.kim7@gmail.com.
3
Department of Neurology, Chonnam National University Hospital, Gwangju, South Korea.
4
Department of Neurology, Chonnam National University Hwasun Hospital, Hwasun, South Korea.

Abstract

BACKGROUND:

Clinical subtypes of Parkinson's disease (PD) have been empirically defined based on the prominent motor symptoms. The aim of this study was to compare the prevalence of non-motor symptoms across PD motor subtypes in patients with PD.

METHODS:

A total of 192 patients with de novo PD were included. The patients were classified into the tremor-dominant/mixed/akinetic-rigid (TD/mixed/AR) and tremor-dominant/mixed/postural instability and gait disturbance (TD/mixed/PIGD) subtypes, according to previous reports.

RESULTS:

In the TD/mixed/AR classification, scores for scales related to motor symptoms and activities of daily living (ADL) were significantly different among the groups, and patients with the AR subtype demonstrated more severe scores than patients with the TD subtype. In the TD/mixed/PIGD classification, age, age at symptom onset, scores on motor-related scales, ADL, and non-motor symptoms were significantly different among the groups. Scores including the modified Hoehn and Yahr stages, the motor and ADL subscores of the Unified Parkinson's Disease Rating Scale, the Beck Depression Inventory, and the Non-Motor Symptom Assessment Scale were significantly different after adjustments for age and age at symptom onset, and patients with the PIGD subtype obtained more severe scores than patients with the TD subtype.

CONCLUSION:

The TD/mixed/PIGD classification seems to be more suitable for identifying non-motor abnormalities than the TD/mixed/AR classification.

KEYWORDS:

Akinetic-rigid; Disease subtypes; Parkinson's disease; Postural instability; Tremor-dominant

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