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EBioMedicine. 2018 May;31:150-156. doi: 10.1016/j.ebiom.2018.04.012. Epub 2018 Apr 17.

Replication of a Gene-Diet Interaction at CD36, NOS3 and PPARG in Response to Omega-3 Fatty Acid Supplements on Blood Lipids: A Double-Blind Randomized Controlled Trial.

Author information

1
Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake University, Hangzhou 310024, China; Institute of Nutrition and Health, Qingdao University, Qingdao 266071, China; Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, China; MRC Epidemiology Unit, University of Cambridge, Cambridge CB20QQ, UK. Electronic address: zhengjusheng@wias.org.cn.
2
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, Shanghai 200011, China; Department of Clinical Nutrition, Zhejiang Hospital, Hangzhou 310000, China.
3
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
4
Wuhan Puai Hospital of Tongji Medical Colledge, Huazhong University of Science and Technology, Wuhan 430034, China.
5
Second Provincial People's Hospital of Gansu, Lanzhou, 730000, China.
6
Department of Endocrinology, Changshan People's Hospital, Changshan 324200, China.
7
Institute of Nutrition and Health, Qingdao University, Qingdao 266071, China.
8
Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, China.
9
USDA Agricultural Research Service, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
10
Institute of Nutrition and Health, Qingdao University, Qingdao 266071, China; Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, China. Electronic address: duoli@qdu.edu.cn.

Abstract

BACKGROUND:

Modulation of genetic variants on the effect of omega-3 fatty acid supplements on blood lipids is still unclear.

METHODS:

In a double-blind randomized controlled trial, 150 patients with type 2 diabetes (T2D) were randomized into omega-3 fatty acid group (n = 56 for fish oil and 44 for flaxseed oil) and control group (n = 50) for 180 days. All patients were genotyped for genetic variants at CD36 (rs1527483), NOS3 (rs1799983) and PPARG (rs1801282). Linear regression was used to examine the interaction between omega-3 fatty acid intervention and CD36, NOS3 or PPARG variants for blood lipids.

FINDINGS:

Significant interaction with omega-3 fatty acid supplements was observed for CD36 on triglycerides (p-interaction = 0.042) and PPAGR on low-density lipoprotein-cholesterol (p-interaction = 0.02). We also found a significant interaction between change in erythrocyte phospholipid omega-3 fatty acid composition and NOS3 genotype on triglycerides (p-interaction = 0.042), total cholesterol (p-interaction = 0.013) and ratio of total cholesterol to high-density lipoprotein cholesterol (p-interaction = 0.015). The T2D patients of CD36-G allele, PPARG-G allele and NOS3-A allele tended to respond better to omega-3 fatty acids in improving lipid profiles. The interaction results of the omega-3 fatty acid group were mainly attributed to the fish oil supplements.

INTERPRETATION:

This study suggests that T2D patients with different genotypes at CD36, NOS3 and PPARG respond differentially to intervention of omega-3 supplements in blood lipid profiles.

KEYWORDS:

Diabetes; Genetic variants; Interaction; Omega-3 fatty acids; Randomized controlled trial

PMID:
29703528
PMCID:
PMC6013782
DOI:
10.1016/j.ebiom.2018.04.012
[Indexed for MEDLINE]
Free PMC Article

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