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Scand J Clin Lab Invest. 2018 Jul;78(4):312-317. doi: 10.1080/00365513.2018.1467035. Epub 2018 Apr 27.

Significance of asymptomatic hyperuricemia in patients after coronary events.

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a Department of Internal Medicine, Faculty of Medicine , University of Niš , Niš , Serbia.
b Institute for Therapy and Rehabilitation 'Niška Banja' , Niška Banja , Serbia.
c Faculty of Medicine , University of Niš , Niš , Serbia.
d American University , Washington , DC , USA.
e Johns Hopkins University , Baltimore , MD , USA.
f Veterans Affairs Medical Center Washington USA , Washington , DC , USA.


The goal of the present study was to determine the prevalence of hyperuricemia in patients with coronary artery disease (CAD), within three months after coronary events. Also, we aimed to determine whether the presence of hyperuricemia holds correlation with severe CAD, overall heart functioning and risk factors for CAD. The study included 505 consecutive CAD patients, 385 males and 120 females, aged 60.9 ± 9.6 years, with a mean body mass index (BMI) 28.0 ± 3.7 kg/m2. All patients were admitted to specialized cardiovascular rehabilitation within three months post-acute myocardial infarction (AMI) without revascularization (32.6%), percutaneous coronary intervention (PCI) with myocardial infarction (32.1%) and with coronary bypass graft (35.3%). The mean value of serum acidum uricum (SUA) was 345.5 ± 100.3 µmol/L, where 115 (22.8%) patients had asymptomatic hyperuricemia. Patients with asymptomatic hyperuricemia had significantly higher average number of risk factors, lower HDL cholesterol and higher creatinine and triglycerides levels, lower ejection fraction (EF). Multivariate stepwise analysis revealed that five parameters were capable to predict SUA levels. We can conclude that in patients with CAD, SUA levels are independently associated with BMI, triglyceride and creatinine levels and negatively with EF. Thus, one can say that asymptomatic hyperuricemia is not significantly associated with the severity of CAD.


Uric acid; asymptomatic hyperuricemia; coronary artery disease; ischemic heart disease; myocardial infarction

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