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Am J Perinatol. 2018 Oct;35(12):1213-1221. doi: 10.1055/s-0038-1642059. Epub 2018 Apr 27.

Neonatal Morbidities among Moderately Preterm Infants with and without Exposure to Antenatal Corticosteroids.

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Department of Pediatrics, Children's Hospital of Michigan and Hutzel Women's Hospital, Detroit, Michigan.
Biostatistics and Epidemiology Division, RTI International, Rockville, Maryland.
Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio.
Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Department of Pediatrics, Women and Infants' Hospital of Rhode Island, Providence, Rhode Island.
Division of Neonatal and Developmental Medicine, Stanford University, Palo Alto, California.
Department of Pediatrics, University of Rochester, Rochester, New York.
McGovern Medical School at the University of Texas Health Science Center, Houston, Texas.
Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.



 We aimed to compare the rates of "surfactant treated respiratory disease" and other neonatal morbidities among moderately preterm (MPT) infants exposed to no, partial, or a complete course of antenatal corticosteroids (ANS).


 This observational cohort study evaluated MPT infants (290/7-336/7 weeks' gestational age), born between January 2012 and November 2013 and enrolled in the "MPT Registry" of the National Institute of Child Health and Human Development Neonatal Research Network.


 Data were available for 5,886 infants, including 676 with no exposure, 1225 with partial, and 3,985 with a complete course of ANS. Among no, partial, and complete ANS groups, respectively, there were significant differences in rates of delivery room resuscitation (4.1, 1.4, and 1.2%), surfactant-treated respiratory disease (26.5, 26.3, and 20%), and severe intracranial hemorrhage (3, 2, and 0.8%). Complete ANS course was associated with lower surfactant-treated respiratory disease, compared with partial ANS (odds ratio [OR] 0.62; 95% confidence interval [CI] 0.52-0.74), and no ANS groups (OR 0.52; 95% CI 0.41-0.66) on adjusted analysis.


 In MPT infants, ANS exposure is associated with lower delivery room resuscitation, surfactant-treated respiratory disease, and severe intracranial hemorrhage; with the lowest frequency of morbidities associated with a complete course.

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