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World Neurosurg. 2018 Jul;115:e592-e598. doi: 10.1016/j.wneu.2018.04.106. Epub 2018 Apr 24.

Intracranial Arterial Fenestration and Risk of Aneurysm: A Systematic Review and Meta-Analysis.

Author information

1
Department of Medical Imaging, the Affiliated Hospital of Jining Medical University, Jining, China.
2
Department of Medical Imaging, the Affiliated Hospital of Jining Medical University, Jining, China. Electronic address: sdjnchenyueqin@163.com.
3
Department of Medical Imaging, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Abstract

BACKGROUND:

Previous studies have been inconsistent regarding risk for intracranial aneurysm related to intracranial arterial fenestration. We conducted a meta-analysis to examine the association between intracranial arterial fenestration and risk of aneurysm.

METHODS:

We performed a systematic review of PubMed and Embase through August 2017 for potentially relevant articles. Summary odds ratios with 95% confidence intervals were pooled using a random-effects model.

RESULTS:

Of 446 articles found, 7 were selected for meta-analysis. Pooled odds ratios revealed an increased risk of aneurysm owing to fenestration of 1.50 (95% confidence interval, 0.61-3.71; P = 0.38). Subgroup analyses based on the population presenting with various indications suggested that pooled odds ratios indicated a significant increase in risk for aneurysm of 2.43 (95% confidence interval, 1.04-5.69; P = 0.04).

CONCLUSIONS:

Our findings indicate that intracranial arterial fenestration may be associated with increased risk for aneurysm formation.

KEYWORDS:

Angiography; Central nervous system vascular malformations; Intracranial aneurysm; Meta-analysis; Spontaneous subarachnoid hemorrhage

PMID:
29702312
DOI:
10.1016/j.wneu.2018.04.106
[Indexed for MEDLINE]

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