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Clin Exp Pharmacol Physiol. 2018 Apr 27. doi: 10.1111/1440-1681.12957. [Epub ahead of print]

The influence of ABCB1 and P2Y12 genetic variants on clinical outcomes in Chinese intracranial artery stenosis patients.

Li X1,2, Jiang L3, Sun S4, Li W2, Li X5, Miao Z5, Zhao Z1,2, Ma N5.

Author information

1
Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
2
Monogenic Disease Research Center for Neurological Disorders, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
3
Department of Pharmacy, Shanghai Kaiyuan Orthopaedic Hospital, Shanghai, People's Republic of China.
4
College of Pharmacy and Health Sciences, Western New England University, Springfield, Massachusetts, United States of America.
5
Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China.

Abstract

For intracranial artery stenosis patients, high inter-individual variability in response to antiplatelet drug therapy results in recurrent ischemic events. We aimed to evaluate the association of drug-related genetic polymorphisms with adverse clinical outcomes. We consecutively enrolled 157 patients receiving dual-antiplatelet therapy (aspirin plus clopidogrel), and adverse clinical events occurred in 10 patients during the one year follow-up. The P2Y12 polymorphisms (rs9859538 and rs10935842) were associated with increased likelihood of relapse events (OR=2.934, 95%CI=1.022-8.425, P-value=0.045), and the two variants are in complete linkage disequilibrium. The mutation of ABCB1 rs1128503 may decrease the recurrence of clinical events (OR=0.211, 95%CI=0.046-0.957, P-value=0.044). Genetic testing (ABCB1 and P2Y12) may provide useful information to prevent ischemic events prior to the initiation of antiplatelet therapy. This article is protected by copyright. All rights reserved.

KEYWORDS:

ABCB1; P2Y12; ischemic stroke; polymorphism

PMID:
29701913
DOI:
10.1111/1440-1681.12957

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