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J Antibiot (Tokyo). 2018 Aug;71(8):753-756. doi: 10.1038/s41429-018-0058-7. Epub 2018 Apr 26.

Anti-inflammatory phomalichenones from an endolichenic fungus Phoma sp.

Kim JW1, Ko W2, Kim E1,3, Kim GS1,3, Hwang GJ1,3, Son S1, Jeong MH4, Hur JS4, Oh H2, Ko SK1,3, Jang JH5,6, Ahn JS7,8.

Author information

1
Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Republic of Korea.
2
College of Pharmacy, Wonkwang University, Iksan, 54538, Republic of Korea.
3
Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, 34113, Republic of Korea.
4
Korean Lichen Research Institute, Sunchon National University, Suncheon, 57922, Republic of Korea.
5
Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Republic of Korea. jangjh@kribb.re.kr.
6
Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, 34113, Republic of Korea. jangjh@kribb.re.kr.
7
Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Republic of Korea. jsahn@kribb.re.kr.
8
Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, 34113, Republic of Korea. jsahn@kribb.re.kr.

Abstract

Four new compounds, phomalichenones A-D (1-4), and seven known compounds (5-11) were isolated from the cultures of an endolichenic fungus Phoma sp. EL002650. Their structures were determined by the analysis of their spectroscopic data (NMR and MS). Compounds 1 and 6 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. In addition, compound 1 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin(IL)-1β, and IL-6.

PMID:
29700423
DOI:
10.1038/s41429-018-0058-7
[Indexed for MEDLINE]

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