Format

Send to

Choose Destination
Kaohsiung J Med Sci. 2018 May;34(5):255-262. doi: 10.1016/j.kjms.2017.11.004. Epub 2017 Dec 6.

Mulberry anthocyanins improves thyroid cancer progression mainly by inducing apoptosis and autophagy cell death.

Author information

1
Department of Breast and Thyroid Surgery, Tengzhou Central People's Hospital, Tengzhou City, Shangdong Province, PR China.
2
Department of Ultrasound Tengzhou Central People's Hospital, Tengzhou City, Shangdong Province, PR China.
3
Department of Breast and Thyroid Surgery, Tengzhou Central People's Hospital, Tengzhou City, Shangdong Province, PR China. Electronic address: liubin7777@126.com.

Abstract

Dietary anthocyanin compounds have multiple biological effects, including antioxidant, anti-inflammatory, and anti-atherosclerotic characteristics. The present study evaluated the anti-tumor capacity of mulberry anthocyanins (MA) in thyroid cancer cells. Our data showed that MA suppressed SW1736 and HTh-7 cell proliferation in a time- and dose-dependent manner. Meanwhile, flow cytometry results indicated that MA significantly increased SW1736 and HTh-7 cell apoptosis. We additionally observed that SW1736 and HTh-7 cell autophagy was markedly enhanced after MA treatment. Importantly, anthocyanin-induced cell death was largely abolished by 3-methyladenine (3-MA) or chloroquine diphosphate salt (CQ) treatment, suggesting that MA-induced SW1736 and HTh-7 cell death was partially dependent on autophagy. In addition, activation of protein kinase B (Akt), mammalian target of rapamycin (mTOR), and ribosomal protein S6 (S6) were significantly suppressed by anthocyanin exposure. In summary, MA may serve as an adjunctive therapy for thyroid cancer patients through induction of apoptosis and autophagy-dependent cell death.

KEYWORDS:

Apoptosis; Autophagic death; Mulberry anthocyanins; Thyroid cancer

PMID:
29699632
DOI:
10.1016/j.kjms.2017.11.004
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center