Defects are often observed in crystalline structures. To regulate the formation or annihilation of defects presents an interesting question. In this work, we propose a method to fabricate defect patterns composed of regularly distributed steady "programmed defects", which is proceeded via the heterogeneous nucleation of a hexagonal pattern from a homogeneous state. The nucleation process occurring in a model system of AB-diblock/C-homopolymer blends under polygonal confinement is modeled by the time-dependent Ginzburg-Landau theory and is simulated by the cell dynamics simulations. Specifically, we demonstrate the validity of this method by means of three polygonal confinements including square, pentagon, and octagon, which have mismatched angles with the hexagonal lattice. Each corner or side of the polygons induces a nucleation event separately. Two nucleated domain grains by two neighboring corners or sides exhibit incommensurate orientations, and thus their merging leads to a radial line of clustered defects in the form of five-seven pairs. As a result, these radial lines constitute a radial pattern of defects, and their number is equal to the side number of the polygon. The distance of five-seven defect pairs is dictated by the incommensurate angle between two neighboring grains, which is similar to that of defects in hard crystals. This method can be extended to fabricate diverse defect patterns by programming the nucleation agents beyond simple polygonal confinements.