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Int J Surg Case Rep. 2018;46:69-73. doi: 10.1016/j.ijscr.2018.04.011. Epub 2018 Apr 16.

Goblet cell carcinoid of the appendix: Case report of a high grade tumor in a 20-year-old.

Author information

1
Department of Surgery, The Cambridge Hospital, Harvard Medical School, Cambridge, MA, USA. Electronic address: Ameen_Barghi@hms.harvard.edu.
2
Department of Pathology, The Cambridge Hospital, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA, USA.
3
Department of Surgery, The Cambridge Hospital, Harvard Medical School, Cambridge, MA, USA.

Abstract

INTRODUCTION:

Goblet cell carcinoid (GCC) is an extraordinarily rare appendiceal tumor that is usually an incidental diagnosis on post-operative histology. It typically presents in the fifth or sixth decade of life. Our patient is the only reported case study of GCC in a pediatric-young adult. Due to its potentially poor prognosis, GCC is surgically treated as an adenocarcinoma, with right hemicolectomy as the mainstay of treatment.

PRESENTATION OF CASE:

The patient was a 20-year-old male who presented with a history, physical exam, and work up consistent with acute appendicitis. He underwent an uneventful laparoscopic appendectomy and was diagnosed with a high grade GCC post-operatively.

DISCUSSION:

GCC is a rare tumor of the appendix with unique histological features including small rosettes with crescentic nuclei distended with mucin. It is often retroactively diagnosed with histology after a majority of patients present with acute appendicitis symptoms. The behavior of this tumor in pediatric-young adults is very poorly understood.

CONCLUSION:

We review the literature for GCC of the appendix and illustrate a case report of a young, otherwise healthy 20-year-old who presented as appendicitis. Although rare, neoplasm must be kept in mind while offering non-operative management for acute appendicitis.

KEYWORDS:

Appendectomy; Appendix; Goblet cell carcinoid; Pediatric; Surgery; Young

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