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Int J Surg Case Rep. 2018;46:69-73. doi: 10.1016/j.ijscr.2018.04.011. Epub 2018 Apr 16.

Goblet cell carcinoid of the appendix: Case report of a high grade tumor in a 20-year-old.

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Department of Surgery, The Cambridge Hospital, Harvard Medical School, Cambridge, MA, USA. Electronic address:
Department of Pathology, The Cambridge Hospital, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA, USA.
Department of Surgery, The Cambridge Hospital, Harvard Medical School, Cambridge, MA, USA.



Goblet cell carcinoid (GCC) is an extraordinarily rare appendiceal tumor that is usually an incidental diagnosis on post-operative histology. It typically presents in the fifth or sixth decade of life. Our patient is the only reported case study of GCC in a pediatric-young adult. Due to its potentially poor prognosis, GCC is surgically treated as an adenocarcinoma, with right hemicolectomy as the mainstay of treatment.


The patient was a 20-year-old male who presented with a history, physical exam, and work up consistent with acute appendicitis. He underwent an uneventful laparoscopic appendectomy and was diagnosed with a high grade GCC post-operatively.


GCC is a rare tumor of the appendix with unique histological features including small rosettes with crescentic nuclei distended with mucin. It is often retroactively diagnosed with histology after a majority of patients present with acute appendicitis symptoms. The behavior of this tumor in pediatric-young adults is very poorly understood.


We review the literature for GCC of the appendix and illustrate a case report of a young, otherwise healthy 20-year-old who presented as appendicitis. Although rare, neoplasm must be kept in mind while offering non-operative management for acute appendicitis.


Appendectomy; Appendix; Goblet cell carcinoid; Pediatric; Surgery; Young

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