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Respir Physiol Neurobiol. 2018 Nov;257:115-121. doi: 10.1016/j.resp.2018.04.009. Epub 2018 Apr 23.

The effect of adenoidectomy on cough reflex sensitivity in atopic children.

Author information

1
Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM CU), Department of Pathological Physiology JFM CU and Biomedical Center Martin JFM CU, Slovak Republic; Slovak Medical University in Bratislava, Faculty of Medicine, The Clinic of Otorhinolaryngology and Head and Neck Surgery, Central Military Hospital, Ruzomberok, Slovak Republic.
2
Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, The Clinic of Children and Adolescents, University Hospital, Martin, Slovak Republic.
3
Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM CU), Department of Pathological Physiology JFM CU and Biomedical Center Martin JFM CU, Slovak Republic.
4
Outpatient Department of Clinical Immunology and Allergology, Ruzomberok, Slovak Republic.
5
Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM CU), Department of Bioinformatics of Biomedical Center Martin JFM CU, Slovak Republic.
6
Clinic of Paediatric Respiratory Diseases and Tuberculosis JFM CU, National Institute of Paediatric Tuberculosis and Respiratory Diseases, Dolny Smokovec, Slovak Republic.
7
Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM CU), Clinic of Internal Medicine I, JLF CU, Slovak Republic.
8
Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM CU), Department of Pathological Physiology JFM CU and Biomedical Center Martin JFM CU, Slovak Republic. Electronic address: pecova@jfmed.uniba.sk.

Abstract

The aim of this study was to determine whether cough sensitivity is changed after adenoidectomy in atopic children with chronic cough. 21 Children having symptoms of chronic cough and adenoid hypertrophy verified by nasal fiberoptic endoscopy were submitted to cough sensitivity measurement before and after adenoidectomy. Their pulmonary function was within normal range. Concentrations of capsaicin causing two (C2) and five coughs (C5) were reported. Children' (14 boys and 7 girls, mean age 6,52 yrs) cough sensitivity (geometric mean, with 95% CI) for C2 was preoperatively (before adenoidectomy) 19.95 (9.95-39.98) micromol/l vs. children' C2 postoperatively 14.04 (7.16-27.55) (P = .083 for Wilcoxon paired two sample test). Children' C5 was preoperatively 86.26 (39.25-189.57) micromol/l vs. C5 postoperatively 95.23 (46.33-195.75) micromol/l (P = .794 for Wilcoxon paired two sample test). We conclude that cough sensitivity for C2 and C5 was not significantly changed after adenoidectomy in atopic children with chronic cough.

KEYWORDS:

Adenoidectomy; Atopy; Children; Cough; Cough reflex sensitivity

PMID:
29698696
DOI:
10.1016/j.resp.2018.04.009
[Indexed for MEDLINE]

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