Send to

Choose Destination
Liver Transpl. 2018 Sep;24(9):1221-1232. doi: 10.1002/lt.25185.

Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study.

Author information

Departments of Medical Social Sciences, Surgery, and Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL.
Departments of Psychiatry, Psychology, Epidemiology, Biostatistics, and Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA.
Arbor Research Collaborative for Health, Ann Arbor, MI.
Department of Transplantation, Lahey Hospital and Medical Center, Burlington, MA.
Department of Biostatistics, University of Michigan, Ann Arbor, MI.
Department of Psychology, University of British Columbia, Kelowna, British Columbia, Canada.
Department of Surgery, University of Pennsylvania, Philadelphia, PA.
Division of Transplantation, The Transplant Institute Beth Israel Deaconess Medical Center, Harvard University, Boston, MA.
Department of Psychiatry, Columbia University, New York, NY.
Departments of Medicine and Surgery, University of California at San Francisco, San Francisco, CA.
Department of Medicine, University of Colorado, Denver, Aurora, CO.
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.


Little is known about living liver donors' perceptions of their physical well-being following the procedure. We collected data on donor fatigue, pain, and other relevant physical outcomes as part of the prospective, multicenter Adult-to-Adult Living Donor Liver Transplantation Cohort Study consortium. A total of 271 (91%) of 297 eligible donors were interviewed at least once before donation and 3, 6, 12, and 24 months after donation using validated measures when available. Repeated measures regression models were used to identify potential predictors of worse physical outcomes. We found that donors reported more fatigue immediately after surgery that improved by 2 years after donation, but not to predonation levels. A similar pattern was seen across a number of other physical outcomes. Abdominal or back pain and interference from their pain were rated relatively low on average at all study points. However, 21% of donors did report clinically significant pain at some point during postdonation study follow-up. Across multiple outcomes, female donors, donors whose recipients died, donors with longer hospital stays after surgery, and those whose families discouraged donation were at risk for worse physical well-being outcomes. In conclusion, although not readily modifiable, we have identified risk factors that may help identify donors at risk for worse physical outcomes for targeted intervention. Liver Transplantation 00 000-000 2018 AASLD.

[Available on 2019-09-01]
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center