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FEBS Lett. 1988 Aug 1;235(1-2):211-4.

The hydrolysis of ATP that accompanies actin polymerization is essentially irreversible.

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1
Laboratoire d'Enzymologie, CNRS, Gif-sur-Yvette, France.

Abstract

The hydrolysis of ATP that accompanies the polymerization of actin occurs on the F-actin subsequent to the addition of the G-ATP-actin subunit to the elongating filament. We now show that this ATP hydrolysis is essentially irreversible. Thus, a large decrease in free energy occurs at the cleavage step, F-ATP-actin----F-ADP-Pi-actin.

PMID:
2969829
[Indexed for MEDLINE]
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