Format

Send to

Choose Destination
Expert Rev Vaccines. 2018 May;17(5):421-433. doi: 10.1080/14760584.2018.1470507. Epub 2018 May 7.

Vaccines for healthcare-associated infections: present, future, and expectations.

Author information

1
a Inserm, CIC 1408, I-REIVAC , University Hospital of Saint-Etienne , Saint-Etienne , France.
2
b GIMAP EA 3064 , University of Lyon , Saint-Etienne , France.
3
c Inserm CIC 1417, I-REIVAC, University of Paris-Descartes , University Hospital of Cochin-Broca-Hôtel-Dieu , Paris , France.
4
d Infection control unit , University Hospital of Saint-Etienne , Saint-Etienne , France.

Abstract

INTRODUCTION:

In spite of the widespread implementation of preventive strategies, the prevalence of healthcare-associated infections (HAIs) remains high. HAIs are associated with multidrug resistant organisms, and in the post-antibiotic era, alternative strategies such as vaccines are needed for their management.

AREAS COVERED:

Vaccines to prevent HAIs could be proposed to at-risk patients, or to healthcare workers (HCWs) to prevent cross-transmission. After searches in Pubmed and clinicaltrials.gov, existing vaccines and vaccines under clinical development are presented in this narrative review. Issues associated with the use of vaccines to prevent HAIs are discussed.

EXPERT COMMENTARY:

Future vaccines against HAIs will contribute to fight antibiotic resistance and thus reduce the burden of HAIs. At this stage, the goal of obtaining effective vaccines against S.aureus, C. difficile and gram-negative bacteria has not yet been achieved. Obtaining an efficient response to vaccines in at-risk patients for HAIs is also challenging, and future strategies of vaccination need to address this difficulty. The efficacy of vaccines for HCWs in reducing the spread of nosocomial outbreaks is counterbalanced by the lack of adherence to vaccine policies among HCWs. The acceptance of future vaccines to prevent carriage and infection with organisms involved in HAIs in HCWs will probably be a challenge.

KEYWORDS:

Healthcare-associated infections; antimicrobial resistance; cross-transmission; immunization; prevention; vaccines

PMID:
29697286
DOI:
10.1080/14760584.2018.1470507
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center