Format

Send to

Choose Destination
Nutr Diabetes. 2018 Apr 25;8(1):18. doi: 10.1038/s41387-018-0027-z.

Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction.

Author information

1
Division of Reproductive Sciences, Department of Obstetrics & Gynecology, School of Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USA. jenifer.monks@ucdenver.edu.
2
Pathology Department, School of Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USA.
3
Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
4
Division of Reproductive Sciences, Department of Obstetrics & Gynecology, School of Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USA.
5
Division of Endocrinology, Metabolism, & Diabetes, Department of Medicine, School of Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USA.
6
Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Abstract

BACKGROUND/OBJECTIVES:

The current obesity epidemic has spurred exploration of the developmental origin of adult heath and disease. A mother's dietary choices and health can affect both the early wellbeing and lifelong disease-risk of the offspring.

SUBJECTS/METHODS:

To determine if changes in the mother's diet and adiposity have long-term effects on the baby's metabolism, independently from a prenatal insult, we utilized a mouse model of diet-induced-obesity and cross-fostering. All pups were born to lean dams fed a low fat diet but were fostered onto lean or obese dams fed a high fat diet. This study design allowed us to discern the effects of a poor diet from those of mother's adiposity and metabolism. The weaned offspring were placed on a high fat diet to test their metabolic function.

RESULTS:

In this feeding challenge, all male (but not female) offspring developed metabolic dysfunction. We saw increased weight gain in the pups nursed on an obesity-resistant dam fed a high fat diet, and increased pathogenesis including liver steatosis and adipose tissue inflammation, when compared to pups nursed on either obesity-prone dams on a high fat diet or lean dams on a low fat diet.

CONCLUSION:

Exposure to maternal over-nutrition, through the milk, is sufficient to shape offspring health outcomes in a sex- and organ-specific manner, and milk from a mother who is obesity-prone may partially protect the offspring from the insult of a poor diet.

PMID:
29695710
PMCID:
PMC5916951
DOI:
10.1038/s41387-018-0027-z
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center