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In Vivo. 2018 May-Jun;32(3):499-505.

Activated Ductal Proliferation Induced by N-Nitrosobis (2-oxopropyl)amine in Fat-infiltrated Pancreas of KK-Ay Mice.

Author information

1
Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
2
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
3
Central Animal Division, National Cancer Center Research Institute, Tokyo, Japan.
4
Central Animal Division, National Cancer Center Research Institute, Tokyo, Japan mtakahas@ncc.go.jp.

Abstract

BACKGROUND/AIM:

Our aim was to investigate whether tissue with fatty infiltration within the lobes of the pancreas (scattered FI) is sensitive to carcinogen-induced pancreatic ductal proliferation.

MATERIALS AND METHODS:

Seven-week-old female C57BL/6J, C57BL/6J-Ay, KK-Ay, and ICR mice were subcutaneously treated with N-nitrosobis(2-oxopropyl) amine at a dose of 80 mg/kg body weight, and the differences in damage-induced cell proliferation and their biochemical data were compared 2 days after.

RESULTS:

Scattered FI in the pancreas was obvious only in KK-Ay mice, which have high serum lipid, leptin and insulin levels, and cell proliferation both in pancreatic and common bile ducts was enhanced only in KK-Ay mice by the carcinogen treatment.

CONCLUSION:

Scattered FI in the pancreas per se can be an important factor for carcinogenesis. The genetic background causing scattered FI of the pancreas should be further investigated.

KEYWORDS:

Fatty infiltration; mouse; pancreatic cancer; proliferation; type 2 diabetes mellitus

PMID:
29695552
DOI:
10.21873/invivo.11267
[Indexed for MEDLINE]

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