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Rejuvenation Res. 2018 Dec;21(6):506-509. doi: 10.1089/rej.2017.2037. Epub 2018 Jun 20.

Restoring NAD(+) Levels with NAD(+) Intermediates, the Second Law of Thermodynamics, and Aging Delay.

Author information

1
1 Laboratory of Oxidative Stress Research, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia.
2
2 Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Abstract

The hypothesis regarding the role of increased nicotinamide adenine dinucleotide (NAD+) levels with reference to the fundamental concepts of aging and entropy is presented. Considering the second law of thermodynamics, NAD+ seems the appropriate candidate for reversing many aging-associated pathologies. NAD+ is presented as an essential compound that enables organisms to stay highly organized and well maintained, with a lower entropy state.

KEYWORDS:

NAD+; aging delay; entropy; second law of thermodynamics

PMID:
29695187
DOI:
10.1089/rej.2017.2037
[Indexed for MEDLINE]

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