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Nanoscale. 2018 May 17;10(19):8947-8952. doi: 10.1039/c8nr01516c.

Deciphering the role of substrate stiffness in enhancing the internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers.

Author information

1
BioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering Graduate Program, School of Engineering, University of Kansas, Lawrence, KS, USA. arghyapaul@ku.edu.

Abstract

This study investigates the role of substrate stiffness in the non-viral transfection of human adipose-derived stem cells (hASCs) with the aim to maximize the hASC expression of vascular endothelial growth factor (VEGF). The results confirm the direct effect of substrate stiffness in regulating cytoskeletal remodeling and corresponding plasmid internalization.

PMID:
29693099
PMCID:
PMC5957767
DOI:
10.1039/c8nr01516c
[Indexed for MEDLINE]
Free PMC Article

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