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Drugs Context. 2018 Apr 17;7:212530. doi: 10.7573/dic.212530. eCollection 2018.

Emollient treatment of atopic dermatitis: latest evidence and clinical considerations.

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1
Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong.

Abstract

Aim:

To review current classes of emollients in the market, their clinical efficacy in atopic dermatitis (AD) and considerations for choice of an emollient.

Methods:

PubMed Clinical Queries under Clinical Study Categories (with Category limited to Therapy and Scope limited to Narrow) and Systematic Reviews were used as the search engine. Keywords of 'emollient or moisturizer' and 'atopic dermatitis' were used.

Overview of findings:

Using the keywords of 'emollient' and 'atopic dermatitis', there were 105 and 36 hits under Clinical Study Categories (with Category limited to Therapy and Scope limited to Narrow) and Systematic Reviews, respectively. Plant-derived products, animal products and special ingredients were discussed. Selected proprietary products were tabulated.

Conclusions:

A number of proprietary emollients have undergone trials with clinical data available on PubMed-indexed journals. Most moisturizers showed some beneficial effects, but there was generally no evidence that one moisturizer is superior to another. Choosing an appropriate emollient for AD patients would improve acceptability and adherence for emollient treatment. Physician's recommendation is the primary consideration for patients when selecting a moisturizer/emollient; therefore, doctors should provide evidence-based information about these emollients.

KEYWORDS:

atopic dermatitis; emollient

Conflict of interest statement

Disclosure and potential conflicts of interest: The authors declare no conflicts of interest. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors are available for download at: http://www.drugsincontext.com/wp-content/uploads/2018/03/dic.212530-COI.pdf

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