Cyclodextrins as excipients in tablet formulations

Drug Discov Today. 2018 Jun;23(6):1274-1284. doi: 10.1016/j.drudis.2018.04.009. Epub 2018 Apr 22.

Abstract

This paper aims to provide a critical review of cyclodextrins as excipients in tablet formulations, highlighting: (i) the principal pharmaceutical applications of cyclodextrins; (ii) the most relevant technological aspects in pharmaceutical formulation development; and (iii) the actual regulatory status of cyclodextrins. Moreover, several illustrative examples are presented. Cyclodextrins can be used as complexing excipients in tablet formulations for low-dose drugs. By contrast, for medium-dose drugs and/or when the complexation efficiency is low, the methods to enhance the complexation efficiency play a key part in reducing the cyclodextrin quantity. In addition, these compounds are used as fillers, disintegrants, binders and multifunctional direct compression excipients of the tablets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chemistry, Pharmaceutical
  • Cyclodextrins / chemistry*
  • Cyclodextrins / pharmacology
  • Excipients / chemistry*
  • Excipients / pharmacology
  • Humans
  • Tablets

Substances

  • Cyclodextrins
  • Excipients
  • Tablets