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Dev Cell. 2018 Apr 23;45(2):149-150. doi: 10.1016/j.devcel.2018.04.004.

Myonuclear Positioning and Aneurysms Are LINC'd by Ariande.

Author information

1
Program in Biochemistry, Cell and Molecular Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
2
Program in Biochemistry, Cell and Molecular Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: m-baylies@ski.mskcc.org.

Abstract

In this issue of Developmental Cell, Tan et al. (2018) show how a novel player in myonuclear positioning, the ubiquitin ligase Ari-1, regulates levels of Koi, a member of the LINC mechanosensing complex, and affects nuclear morphology and positioning in both Drosophila muscles and human vascular smooth muscle cells.

PMID:
29689191
PMCID:
PMC5937272
[Available on 2019-04-23]
DOI:
10.1016/j.devcel.2018.04.004
[Indexed for MEDLINE]

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