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J Neurol. 2018 Jun;265(6):1432-1442. doi: 10.1007/s00415-018-8857-0. Epub 2018 Apr 23.

Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study.

Author information

1
Department of Neuroscience, Neurology, Uppsala University, 751 85, Uppsala, Sweden. shala.berntsson@neuro.uu.se.
2
Department of Neurology, NorthShore University HealthSystem, Evanston, IL, USA.
3
Division of Medicine, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.
4
Department of Neurology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, MN, USA.
5
Department of Neuroscience, Neurology, Uppsala University, 751 85, Uppsala, Sweden.
6
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
7
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
8
Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
9
Department of Epidemiology and Biostatistics, Georgia State University School of Public Health, Atlanta, Georgia.
10
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA.
11
Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
12
Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
13
Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.
14
Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
15
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.
16
Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
17
Section of Cancer Genetics, Institute of Cancer Research, Sutton, London, Surrey, UK.
18
Department of Laboratory Medicine and Pathology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, MN, USA.
19
Departments of Neurology, Neurosurgery, and Preventive Medicine, The University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
20
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
21
Department of Radiation Sciences Oncology, Umeå University, Umeå, Sweden.

Abstract

BACKGROUND:

The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls.

METHODS:

The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures.

RESULTS:

Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood.

CONCLUSIONS:

Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor ***for developing glioma-related seizures or glioma.

KEYWORDS:

Epileptic seizures; Glioma-related seizures; Observational study (cohort, case–control); Primary brain tumor

PMID:
29687214
PMCID:
PMC5990563
DOI:
10.1007/s00415-018-8857-0
[Indexed for MEDLINE]
Free PMC Article

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