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Ann Clin Transl Neurol. 2018 Mar 7;5(4):499-501. doi: 10.1002/acn3.539. eCollection 2018 Apr.

Head and voice tremor improving with immunotherapy in an anti-NF155 positive CIDP patient.

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Neuromuscular Diseases Unit Department of Neurology Hospital de la Santa Creu i Sant Pau Universitat Autònoma de Barcelona Barcelona Spain.
Department of Neurology Hospital San Pedro Logroño Spain.
Centro para la Investigación Biomédica en Red en Enfermedades Raras CIBERER (Centre for Biomedical Network Research on Rare Diseases) Madrid Spain.


Chronic inflammatory demyelinating polyradiculoneuropathy with NF155 antibodies (anti-NF155+) constitutes a specific chronic inflammatory demyelinating polyradiculoneuropathy subset with a high incidence of limb's tremor and poor response to conventional therapies. We report a patient with chronic inflammatory demyelinating polyradiculoneuropathy anti-NF155+ with a severe tremor involving limbs, head and voice that responded very well to rituximab. This response correlated with a sharp decrease in the anti-NF155 titers. This case is the first report associating head and voice tremor to chronic inflammatory demyelinating polyradiculoneuropathy, reinforces the hypothesis of the cerebellar origin of this tremor and provides indirect evidence that the antibodies may be the cause of the tremor in these patients.

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