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AIDS Res Treat. 2018 Mar 1;2018:2187232. doi: 10.1155/2018/2187232. eCollection 2018.

Childhood Adversities and Physical and Mental Health Outcomes in Adults Living with HIV: Findings from the Ontario HIV Treatment Network Cohort Study.

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The Ontario HIV Treatment Network, Toronto, ON, Canada.
Immunodeficiency Clinic, Toronto General Hospital, Toronto, ON, Canada.
Department of Psychiatry, University of Toronto, ON, Canada.
Department of Psychiatry, Mount Sinai Hospital, Toronto, ON, Canada.
Baycrest Health Sciences, Toronto, ON, Canada.
Dalla Lana School of Public Health, University of Toronto, ON, Canada.
Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
Ontario HIV Treatment Network, Toronto, ON, Canada.


We sought to estimate the prevalence of childhood adversity and examine its relationship with health outcomes among people living with HIV. Study participants included 1409 adults living with HIV and receiving care in Toronto, Canada. Data on childhood adversity, health behaviors, HIV outcome measures, depression, and health-related quality of life (HRQOL) were collected through face-to-face interviews and medical records. Statistical analyses included multivariable linear and logistic regression modeling. The prevalence of any childhood adversity was 71% (individual types ranged from 11% to 44%) and higher prevalence was associated with younger age, Indigenous or African/Caribbean/Black ethnicity, lower socioeconomic status, and higher rates of cigarette smoking and nonmedicinal drug use. Greater number of childhood adversities was associated with greater odds of depression and decreasing mental HRQOL. HIV care providers need to screen for childhood adversities and address childhood trauma within the context of HIV care.

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