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J Neuroimmunol. 2018 Jun 15;319:28-36. doi: 10.1016/j.jneuroim.2018.03.004. Epub 2018 Mar 21.

The circulating levels of CD4+ t helper cells are higher in bipolar disorder as compared to major depressive disorder.

Author information

1
University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands. Electronic address: k.becking@umcg.nl.
2
University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Research School of Behavioural and Cognitive Neurosciences (BCN), Groningen, The Netherlands.
3
University of Münster, Department of Psychiatry and Psychotherapy, Münster, Germany; Erasmus MC, Department of Immunology, Rotterdam, The Netherlands.
4
University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands.
5
University Psychiatric Centre KU, Leuven, Belgium.
6
University of Münster, Department of Psychiatry and Psychotherapy, Münster, Germany.
7
University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Research School of Behavioural and Cognitive Neurosciences (BCN), Groningen, The Netherlands.
8
Erasmus MC, Department of Immunology, Rotterdam, The Netherlands.

Abstract

INTRODUCTION:

Clinical differentiation between bipolar disorder (BD) and major depressive disorder (MDD) is difficult. Research has therefore focused on discriminatory biological markers. Previous studies in MDD reported T cell deficits, while the limited studies in BD reported T cell activation. Studies directly comparing circulating numbers of T cells and T cell subsets between BD and MDD are lacking. The studies in the MOODINFLAME consortium make such a comparison possible.

METHODS:

The number of circulating leukocyte populations (lymphocytes, monocytes, NK cells, B cells, T cells, CD3+CD8+ T cytotoxic cells, CD3+CD4+ T helper cells, Th1, Th2, Th17 and T regulatory cells) was determined using FACS technology in a cohort of 83 euthymic BD patients, 8 BD patients with a current mood episode and 165 healthy controls (HC). Data were compared to those of 34 moderately and 56 severely depressed MDD patients.

RESULTS:

Compared to MDD patients, BD patients showed significantly increased levels of Th17, Th2, Th1 and T regulatory cells (all p < .02). In BD patients, levels of Th17 and T regulatory cells were increased compared to HC (p = .03, p = .02, respectively), while MDD patients showed decreased levels of Th17 and Th2 compared to HC (p = .03, p = .01, respectively). Of the various medications only SSRI/SNRI usage could explain part of the Th2 decrease in MDD.

CONCLUSION:

This study shows CD4+ T helper cell deficits in MDD patients, while normal or even raised levels of these cells were found in BD patients. The differences in CD4+ T helper cell differentiation was most outspoken for Th17 cells.

KEYWORDS:

Bipolar disorder; Leukocyte subset; Major depressive disorder; T cell defect; T helper cell differentiation; Th17; Th2

PMID:
29685287
DOI:
10.1016/j.jneuroim.2018.03.004
[Indexed for MEDLINE]

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