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J Affect Disord. 2018 Aug 1;235:489-498. doi: 10.1016/j.jad.2018.04.059. Epub 2018 Apr 10.

Psychological and genetic risk factors associated with suicidal behavior in Korean patients with mood disorders.

Author information

1
Department of Psychiatry, Ewha Womans University College of medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Republic of Korea. Electronic address: yeon8125@naver.com.
2
Department of Psychiatry, Ewha Womans University College of medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Republic of Korea; Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea. Electronic address: kim_psyche@daum.net.
3
Department of Preventive Medicine, School of Medicine, Ewha Womans University, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Republic of Korea. Electronic address: kkong@ewha.ac.kr.
4
Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea. Electronic address: ewpsyche@snu.ac.kr.
5
Department of Psychiatry, Ewha Womans University College of medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Republic of Korea. Electronic address: psyweon@ewha.ac.kr.
6
Department of Psychiatry, Ewha Womans University College of medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Republic of Korea. Electronic address: park_psyche@daum.net.
7
Department of Psychiatry, Ewha Womans University College of medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Republic of Korea. Electronic address: hsh88@nate.com.
8
Department of Psychiatry, Ewha Womans University College of medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Republic of Korea. Electronic address: 72sooik@ewha.ac.kr.

Abstract

INTRODUCTION:

To prevent suicide, a nationwide important issue in Korea, understanding its etiology is essential. This study aimed to delineate the risk factors for suicidal behavior in mood disorder patients in Korea.

METHODS:

216 patients with mood disorders were recruited. We measured suicidal ideation (SI) and suicide attempt (SA) history and the association of six gene polymorphisms with SB: COMT (rs4680), HTR1A (rs6295), TPH1 (rs1800532), BDNF (rs6265), SLC1A3 (rs2269272), and SLC1A2 (rs4755404).

RESULTS:

Patients in the high-SI and SA groups reported more severe depressive, hopelessness, and anxiety symptoms and lower resilience and used less social support-seeking coping than those in the non-significant SI and non-SA groups. Multivariate logistic analysis revealed that depressive disorder, depressive symptoms, poor social support, and less social support-seeking coping were significant independent predictors of suicidal ideation. After adjustment for covariates, age, alcohol consumption, and the rs4680 AA genotype in the COMT gene were associated with suicide attempt.

LIMITATIONS:

The modest sample size and a relatively few candidate genes are limitations of the study. In addition, there is no normal control group and the retrospective evaluation of SA limits the interpretation of the causal relationship with factors affecting SA.

CONCLUSIONS:

Suicidal behavior in Korean patients with mood disorders may be associated with younger age, alcohol consumption, depressive symptoms, poor social support, less social support-seeking coping, and the COMT rs4680 Met/Met genotype.

KEYWORDS:

COMT gene; Mood disorders; Risk factors; Single nucleotide polymorphism; Suicide; rs4680

PMID:
29684863
DOI:
10.1016/j.jad.2018.04.059
[Indexed for MEDLINE]

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