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Biomed Pharmacother. 2018 Jul;103:800-811. doi: 10.1016/j.biopha.2018.04.016. Epub 2018 Apr 24.

Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.

Lu X1, Liu T2, Chen K3, Xia Y4, Dai W5, Xu S6, Xu L7, Wang F8, Wu L9, Li J10, Li S11, Wang W12, Yu Q13, Feng J14, Fan X15, Zhou Y16, Niu P17, Guo C18.

Author information

1
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China. Electronic address: lxy941016@163.com.
2
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China. Electronic address: klmn1334@sina.com.
3
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China. Electronic address: cutking@126.com.
4
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China. Electronic address: gagaxyj@126.com.
5
Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai Institute of Liver Diseases, Shanghai 200032, China. Electronic address: dai_yue@163.com.
6
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, School of Clinical Medicine of Nanjing Medical University, Shanghai 200072, China. Electronic address: xushizan22@163.com.
7
Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200336, China. Electronic address: xiaoling05@126.com.
8
Department of Oncology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China. Electronic address: fairywong04285@163.com.
9
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China. Electronic address: 15901615767@163.com.
10
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China. Electronic address: sealjj@126.com.
11
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China. Electronic address: lrk678@126.com.
12
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China. Electronic address: 3w_sillywen@tongji.edu.cn.
13
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, School of Clinical Medicine of Nanjing Medical University, Shanghai 200072, China. Electronic address: yuqiang0514@163.com.
14
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China. Electronic address: fengjiao080801@163.com.
15
Department of Gastroenterology, Jinshan Hospital of Fudan University, Jinshan, Shanghai 201508, China. Electronic address: xiaomingfan57@hotmail.com.
16
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China. Electronic address: yqzh02@163.com.
17
Department of Gastroenterology, Shanghai Tenth People's Hospital Chongming Branch, Tongji University School of Medicine, Shanghai 202157, China. Electronic address: niuniu1657@126.com.
18
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China. Electronic address: guochuanyong@hotmail.com.

Abstract

Isorhamnetin, a flavonoid compound extracted from plants' fruit or leaves, like sea buckthorn (Hippophae rhamnoides L.), has many biological functions, including anti-tumor, anti-oxidant and anti-inflammatory effect. The present study is in order to explore the hepatoprotective effect of isorhamnetin on concanavalin A (ConA)-induced acute fulminant hepatitis and the underlying mechanism. Mice were injected with ConA (25 mg/kg) to induce acute fulminant hepatitis, three doses of isorhamnetin (10/30/90 mg/kg) was intraperitoneally administrated about 1 h previously. The serum and liver tissues were harvested at 2, 8, and 24 h after ConA injection. The levels of serum liver enzymes and proinflammatory cytokines were significantly reduced in isorhamnetin administration groups. Besides, isorhamnetin improved pathological damage. Furthermore, isorhamnetin affected P38/PPAR-α pathway, and subsequently regulated the expression of apoptosis and autophagy related proteins. The present study investigated that isorhamnetin inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.

KEYWORDS:

3-methylquercetin; Apoptosis; Autophagy; Concanavalin A; Hepatitis

PMID:
29684859
DOI:
10.1016/j.biopha.2018.04.016
[Indexed for MEDLINE]

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