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Contemp Clin Trials. 2018 Jun;69:55-64. doi: 10.1016/j.cct.2018.04.009. Epub 2018 Apr 22.

The International Childhood Cardiovascular Cohort (i3C) consortium outcomes study of childhood cardiovascular risk factors and adult cardiovascular morbidity and mortality: Design and recruitment.

Author information

1
University of Minnesota Medical School, Department of Pediatrics, 2450 Riverside Avenue, East Building, MB689, Minneapolis, MN 55454, United States. Electronic address: Sinai001@umn.edu.
2
University of Minnesota School of Public Health, Division of Epidemiology and Community Health, Minneapolis, MN, United States. Electronic address: Jacob004@umn.edu.
3
University of Cincinnati Children's Hospital Medical Center, Department of Biostatistics and Epidemiology, Cincinnati, OH 45229, United States. Electronic address: jessica.woo@cchmc.org.
4
Tulane University, School of Public Health and Tropical Medicine, Department of Epidemiology, New Orleans, LA 70112, United States. Electronic address: lbazzano@tulane.edu.
5
University of Iowa, College of Public Health, Department of Epidemiology, Iowa City, IA 52242, United States. Electronic address: Trudy-burns@uiowa.edu.
6
University of Minnesota School of Public Health, Division of Epidemiology and Community Health, Minneapolis, MN, United States. Electronic address: huxxx405@umn.edu.
7
University of Turku, Department of Medicine, Turku, Finland. Electronic address: mataju@utu.fi.
8
Wake Forest School of Medicine, Division of Public Health, Winston Salem, NC, United States. Electronic address: rprineas@wakehealth.edu.
9
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. Electronic address: olli.raitakari@utu.fi.
10
University of Minnesota Medical School, Department of Pediatrics, Minneapolis, MN, United States. Electronic address: stein055@umn.edu.
11
University of Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States. Electronic address: Elaine.Urbina@cchmc.org.
12
Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. Electronic address: Alison.venn@utas.edu.au.
13
National Heart, Lung, and Blood Institute, National Institutes of Health, Washington D.C., United States. Electronic address: Jaquishc@nhlbi.nih.gov.
14
The George Institute for Global Health, University of Oxford, Oxford, United Kingdom. Electronic address: terence.dwyer@georgeinstitute.ox.ac.uk.

Abstract

Although it is widely thought that childhood levels of cardiovascular (CV) risk factors are related to adult CV disease, longitudinal data directly linking the two are lacking. This paper describes the design and organization of the International Childhood Cardiovascular Cohort Consortium Outcomes Study (i3C Outcomes), the first longitudinal cohort study designed to locate adults with detailed, repeated, childhood biological, physical, and socioeconomic measurements and a harmonized database. I3C Outcomes uses a Heart Health Survey (HHS) to obtain information on adult CV endpoints, using mail, email, telephone, and clinic visits in the United States (U.S.) and Australia and a national health database in Finland. Microsoft Access, REsearch Data Capture (REDCap) (U.S.), LimeSurvey (Australia), and Medidata™ Rave data systems are used to collect, transfer and organize data. Self-reported CV events are adjudicated via hospital and doctor-released medical records. After the first two study years, participants (N = 10,968) were more likely to be female (56% vs. 48%), non-Hispanic white (90% vs. 80%), and older (10.4 ± 3.8 years vs. 9.4 ± 3.3 years) at their initial childhood study visit than the currently non-recruited cohort members. Over 48% of cohort members seen during both adulthood and childhood have been found and recruited, to date, vs. 5% of those not seen since childhood. Self-reported prevalences were 0.7% Type 1 Diabetes, 7.5% Type 2 Diabetes, 33% hypertension, and 12.8% CV event. 32% of CV events were judged to be true. I3C Outcomes is uniquely able to establish evidence-based guidelines for child health care and to clarify relations to adult CV disease.

KEYWORDS:

Adult Cardiovascular disease; Childhood cardiovascular risk factors; Collaborative cohort study; Heart health survey; Longitudinal cardiovascular risk study

PMID:
29684544
PMCID:
PMC5964041
[Available on 2019-06-01]
DOI:
10.1016/j.cct.2018.04.009

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