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Eur J Clin Invest. 2018 Nov;48 Suppl 2:e12939. doi: 10.1111/eci.12939. Epub 2018 May 11.

Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment.

Author information

1
Signalling Programme, Babraham Institute, Cambridge, UK.

Abstract

Rac-GTPases and their Rac-GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment.

KEYWORDS:

P-Rex1; Rho-GTPases; Vav; guanine-nucleotide exchange factors; neutrophils; small G proteins

PMID:
29682742
PMCID:
PMC6321979
DOI:
10.1111/eci.12939
[Indexed for MEDLINE]
Free PMC Article

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