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Curr Opin Immunol. 2018 Aug;53:51-57. doi: 10.1016/j.coi.2018.04.001. Epub 2018 Apr 20.

Development of next generation hemagglutinin-based broadly protective influenza virus vaccines.

Author information

1
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
2
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: peter.palese@mssm.edu.

Abstract

Influenza viruses are a severe threat to human health and current vaccines do not provide sufficient protection. The highly variable nature of influenza viruses has made the production of efficacious vaccines a challenge. In recent years, a multitude of novel, broadly reactive influenza virus vaccination approaches have been described. What has long seemed impossible could now become reality in the near future-a new generation of influenza virus vaccines that provides long-lasting and broad protection against seasonal as well as potentially pandemic influenza virus strains. This review will discuss new hemagglutinin-based vaccines and their current stage of development.

PMID:
29680576
DOI:
10.1016/j.coi.2018.04.001

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