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Inflamm Res. 2018 Jul;67(7):617-626. doi: 10.1007/s00011-018-1152-9. Epub 2018 Apr 20.

Effects of different natural extracts in an experimental model of benign prostatic hyperplasia (BPH).

Author information

1
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres No. 31, 98166, Messina, Italy.
2
Department of Biomedical and Biotechnological Science, University of Catania, Catania, Italy.
3
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres No. 31, 98166, Messina, Italy. salvator@unime.it.
4
Department of Pharmacological and Physiological Science, Saint Louis University, St. Louis, USA. salvator@unime.it.

Abstract

OBJECTIVE AND DESIGN:

To characterize the impact of inflammatory process and oxidative stress in the degree of benign prostatic hyperplasia (BPH), a common condition in which chronic inflammation plays a crucial role, we investigated the effect of different plant extract preparations in an in vivo model of BPH as new therapeutic target.

MATERIAL:

BPH was made in rats with daily administration of testosterone propionate (3 mg/kg) for 14 days.

TREATMENT:

Rats were randomized into different groups to receive oral administration of plant extract preparations: Serenoa repens with selenium (SeR 28.5 mg/kg associated with Se 0.005 mg/kg), Teoside (2 mg/kg), and Puryprost (14 mg/kg containing Teoside 50% 2 mg/kg and Epilobium 12 mg/kg).

METHODS:

After 14 days, rats were killed and histological changes, prostate weight and apoptotic pathways were assayed.

RESULTS:

The results obtained demonstrated that the association of treatments reduced prostate weight and hyperplasia, while treatment with Puryprost demonstrated a greater trend of protection compared to the other treatments.

CONCLUSION:

Thus, our results indicate that plant extract could be considered as new useful therapy in the treatment of BPH with particular attention on Puryprost that represents a rational approach to reduce BPH through modulation of inflammatory process and anti-oxidant process.

KEYWORDS:

Benign prostatic hyperplasia; Inflammation; Natural extract; Oxidative stress

PMID:
29679313
DOI:
10.1007/s00011-018-1152-9
[Indexed for MEDLINE]

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