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Ann Clin Lab Sci. 2018 Mar;48(2):158-163.

The Effect of Hyperbaric Oxygen Therapy on Myocardial Perfusion after the Implantation of Drug-Eluting Stents.

Author information

1
Department of Cardiology, The Fourth Hospital of Shijiazhuang, Hebei Province, China.
2
Department of Cardiology, The First Hospital of Handan, Hebei Province, China.
3
Department of Cardiology, The Third Hospital of Hebei Medical University, Hebei Province, China.
4
Department of Nuclear, The Third Hospital of Hebei Medical University, Hebei Province, China.
5
Department of Hyperbaric Oxygen, The Third Hospital of Hebei Medical University, Hebei Province, China.
6
Department of Emergency, The Third Hospital of Hebei Medical University, Hebei Province, China guoxuangongzuo@sina.com.

Abstract

AIM:

The study is to investigate hyperbaric oxygen therapy (HBOT) on myocardial perfusion of patients after the implantation of drug-eluting stents (DES) METHODS: From December 2013 to December 2015, a total of 115 patients with CAD who received DES implantation were included in this retrospective study. They were divided into HBOT group (n=55) and control group (n=60) according to different treatments retrospectively. Gated myocardial perfusion single photon emission computed tomography (SPECT) was conducted in all the patients. Endothelin-1 (ET-1), high sensitivity C reactive protein (hs-CRP) and nitric oxide (NO) were detected by the corresponding assay kits.

RESULTS:

After HBOT treatment in HBOT group, SPECT results showed that the improvement rate of impaired sub-segments in patients of HBOT was significantly higher than that in control group (P<0.05), and the parameters of PFR, TPFR, MFR/3 were displayed with marked differences between the two groups (P<0.05). The laboratory results demonstrated a statistically increased level of NO and decreased levels of ET-1 and hs-CRP between the two groups (P<0.05).

CONCLUSIONS:

HBO may improve myocardial blood perfusion, reduce inflammation and vascular endothelial dysfunction, and further improve myocardial microcirculation in patients after the implantation of drug-eluting stents.

PMID:
29678841
[Indexed for MEDLINE]

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