Correlation of plasma B-type natriuretic peptide levels with metabolic risk markers

Med Clin (Barc). 2018 Dec 21;151(12):481-486. doi: 10.1016/j.medcli.2018.02.009. Epub 2018 Apr 17.
[Article in English, Spanish]

Abstract

Background and objective: Natriuretic peptide type B (BNP) is a marker of myocardium injury. This peptide has been associated with metabolic risk markers, although controversy exists in this regard. The aim of the present study was to determine the correlation of plasma BNP levels with metabolic risk parameters.

Materials and methods: A retrospective, observational study that included 152 patients, who were classified according to their clinical diagnosis as patients with metabolic syndrome. Plasma BNP levels and clinical metabolic parameters were assessed by using Spearmańs rank correlation coefficient.

Results: A significant inverse association with weight (r=-.408; p<.0001) and BMI (r=-.443; p<.001) was obtained. While a positive significant association with systolic pressure (r=.324; p<.001) was observed. A significant decrease was found in BNP levels and components of metabolic syndrome. (p<.05).

Conclusion: Based on the results from this study, we can conclude that BNP determination could be an adequate metabolic marker.

Keywords: Brain-type natriuretic peptide; Metabolic syndrome; Obesidad; Obesity; Péptido natriurético tipo B; Síndrome metabólico.

Publication types

  • Multicenter Study
  • Observational Study

MeSH terms

  • Biomarkers / blood
  • Blood Pressure
  • Body Weight
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Metabolic Syndrome / blood*
  • Metabolic Syndrome / physiopathology
  • Middle Aged
  • Natriuretic Peptide, Brain / blood*
  • Retrospective Studies
  • Statistics, Nonparametric

Substances

  • Biomarkers
  • Natriuretic Peptide, Brain