Format

Send to

Choose Destination
Cell Chem Biol. 2018 Apr 19;25(4):353-355. doi: 10.1016/j.chembiol.2018.04.001.

S Marks the Spot: Linking the Antioxidant Activity of N-Acetyl Cysteine to H2S and Sulfane Sulfur Species.

Author information

1
Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA; Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA; Materials Science Institute, University of Oregon, Eugene, OR 97403, USA.
2
Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA; Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA; Materials Science Institute, University of Oregon, Eugene, OR 97403, USA. Electronic address: pluth@uoregon.edu.

Abstract

N-Acetyl cysteine (NAC) is commonly used as an antioxidant and cytoprotectant, yet a broadly applicable mechanism of these activities has remained elusive. In this issue of Cell Chemical Biology, Ezeriņa et al. (2018) report an alternative mechanism for NAC cytoprotection and antioxidant activity by demonstrating that NAC treatment increases sulfane sulfur production via intermediate H2S generation.

PMID:
29677486
DOI:
10.1016/j.chembiol.2018.04.001
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center