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Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H610-H625. doi: 10.1152/ajpheart.00070.2018. Epub 2018 Apr 20.

A role for collagen type IV in cardiovascular disease?

Author information

1
Department of Clinical Biochemistry and Pharmacology, Odense University Hospital , Odense , Denmark.
2
Centre for Individualized Medicine in Arterial Diseases, Odense University Hospital , Odense , Denmark.
3
Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark , Odense , Denmark.

Abstract

Over the past decade, studies have repeatedly found single-nucleotide polymorphisms located in the collagen ( COL) 4A1 and COL4A2 genes to be associated with cardiovascular disease (CVD), and the 13q34 locus harboring these genes is one of ~160 genome-wide significant risk loci for coronary artery disease. COL4A1 and COL4A2 encode the α1- and α2-chains of collagen type IV, a major component of basement membranes in various tissues including arteries. Despite the growing body of evidence indicating a role for collagen type IV in CVD, remarkably few studies have aimed to directly investigate such a role. The purpose of this review is to summarize the clinical reports linking 13q34 to coronary artery disease, atherosclerosis, and artery stiffening and to assemble the scattered pieces of evidence from experimental studies based on vascular cells and tissue collectively supporting a role for collagen type IV in atherosclerosis and other macrovascular disease conditions.

KEYWORDS:

atherosclerosis; basement membrane; cardiovascular disease; collagen type IV

PMID:
29677463
DOI:
10.1152/ajpheart.00070.2018
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