Format

Send to

Choose Destination
Nutrients. 2018 Apr 20;10(4). pii: E512. doi: 10.3390/nu10040512.

Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease.

Author information

1
University Stone Centre, Department of Urology, University of Bonn, Sigmund-Freud-Straße 25, D-53105 Bonn, Germany. Roswitha.Siener@ukbonn.de.

Abstract

Chronic kidney disease and reduced glomerular filtration rate are risk factors for the development of chronic metabolic acidosis. The prevention or correction of chronic metabolic acidosis has been found to slow progression of chronic kidney disease. Dietary composition can strongly affect acid⁻base balance. Major determinants of net endogenous acid production are the generation of large amounts of hydrogen ions, mostly by animal-derived protein, which is counterbalanced by the metabolism of base-producing foods like fruits and vegetables. Alkali therapy of chronic metabolic acidosis can be achieved by providing an alkali-rich diet or oral administration of alkali salts. The primary goal of dietary treatment should be to increase the proportion of fruits and vegetables and to reduce the daily protein intake to 0.8⁻1.0 g per kg body weight. Diet modifications should begin early, i.e., even in patients with moderate kidney impairment, because usual dietary habits of many developed societies contribute an increased proportion of acid equivalents due to the high intake of protein from animal sources.

KEYWORDS:

alkali citrate; bicarbonate; fruits; kidney disease; metabolic acidosis; protein; urinary stones; urolithiasis; vegetables

PMID:
29677110
PMCID:
PMC5946297
DOI:
10.3390/nu10040512
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center