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J Womens Health (Larchmt). 2018 May;27(5):561-568. doi: 10.1089/jwh.2017.6655. Epub 2018 Apr 20.

Effects of Daily Intake of Calcium and Vitamin D-Enriched Milk in Healthy Postmenopausal Women: A Randomized, Controlled, Double-Blind Nutritional Study.

Author information

1
1 Bone Metabolic Unit (CIBERFES), UGC Endocrinología y Nutrición, Hospital Universitario San Cecilio, Instituto de Investigación Biosanitario de Granada (Ibs. Granada) , Granada, Spain .
2
2 Unidad de Endocrinología y Nutrición, Complejo Hospitalario Torrecardenas , Almeria, Spain .
3
3 Department of Obstetrics and Gynecology, University of Granada , Granada, Spain .
4
4 Palacios Institute of Women's Health , Madrid, Spain .
5
5 Nutrition Department, Biosearch S.A., Granada, Spain .
6
6 Research and Development Department, Lactalis Puleva, Granada, Spain .

Abstract

OBJECTIVE:

To determine the effect of the daily intake of calcium and vitamin D-enriched milk (with or without fructooligosaccharides [FOS]) on vitamin D, bone metabolism, and cardiovascular risk factors.

MATERIALS AND METHODS:

Two-year randomized controlled study, including 500 healthy postmenopausal women, assigned to 500 mL/day of skimmed milk to one of three groups: Low-dose (L): (120 mg/100 mL calcium, vitamin D3 30 UI/100 mL), group A: calcium and vitamin D (180 mg/100 mL and 120 UI/100 mL), and group B: calcium and vitamin D (180 mg/100 mL and 120 UI/100 mL) and FOS (5 g/L). We evaluated serum 25(OH)D, bone mineral density (BMD) by Dual Energy X-ray Absorptiometry, and biochemical data of glucose and lipid metabolism.

RESULTS:

After 24 months, vitamin D concentrations did not change in the control group, but increased in group A and group B, p < 0.001. We observed an increase in femoral neck BMD and an improvement in fasting plasma glucose, HbA1c, total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B 100.

CONCLUSIONS:

Daily intake of milk enriched with calcium and vitamin D in postmenopausal healthy women induces a significant improvement in vitamin D status, a significant increase in BMD at femoral neck, and also favorable effects on glucose and lipid profile.

KEYWORDS:

calcium; nutritional intervention; postmenopausal; vitamin D

PMID:
29676968
DOI:
10.1089/jwh.2017.6655
[Indexed for MEDLINE]

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