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Sci China Life Sci. 2018 Apr;61(4):476-482. doi: 10.1007/s11427-017-9270-x. Epub 2018 Apr 1.

Large-area gold nanohole arrays fabricated by one-step method for surface plasmon resonance biochemical sensing.

Author information

1
State Key Laboratory of Cotton Biology, Key Laboratory of Plant Stress Biology, School of Life Sciences, Henan University, Kaifeng, 475004, China.
2
Key Laboratory for Special Functional Materials of Ministry of Education, Henan University, Kaifeng, 475004, China.
3
International Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, 475004, China.
4
ARC Centre of Nanoscale Biophotonics, Macquarie University, Sydney, NSW 2109, Australia.
5
State Key Laboratory of Cotton Biology, Key Laboratory of Plant Stress Biology, School of Life Sciences, Henan University, Kaifeng, 475004, China. bs@henu.edu.cn.
6
International Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, 475004, China. bs@henu.edu.cn.
7
State Key Laboratory of Cotton Biology, Key Laboratory of Plant Stress Biology, School of Life Sciences, Henan University, Kaifeng, 475004, China. songcp@henu.edu.cn.

Abstract

Surface plasmon resonance (SPR) nanosensors based on metallic nanohole arrays have been widely reported to detect binding interactions in biological specimens. A simple and effective method for constructing nanoscale arrays is essential for the development of SPR nanosensors. In this work, we report a one-step method to fabricate nanohole arrays by thermal nanoimprinting in the matrix of IPS (Intermediate Polymer Stamp). No additional etching process or supporting substrate is required. The preparation process is simple, time-saving and compatible for roll-to-roll process, potentially allowing mass production. Moreover, the nanohole arrays were integrated into detection platform as SPR sensors to investigate different types of biological binding interactions. The results demonstrate that our one-step method can be used to efficiently fabricate large-area and uniform nanohole arrays for biochemical sensing.

KEYWORDS:

biomolecular binding; gold nanohole arrays; nanoimprinting; nanosensor; one-step method

PMID:
29675550
DOI:
10.1007/s11427-017-9270-x
[Indexed for MEDLINE]

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