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NPJ Aging Mech Dis. 2018 Apr 11;4:4. doi: 10.1038/s41514-018-0023-5. eCollection 2018.

Blocking negative effects of senescence in human skin fibroblasts with a plant extract.

Author information

1
Christian Doppler Laboratory for Biotechnology of Skin Aging, Vienna, Austria.
2
2Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria.
3
Department of Biology and Women Beauty, Chanel R&T, Pantin, France.
4
Actives Department, Chanel R&T, Pantin, France.
5
Institute for Diabetes and Cancer (IDC), Helmholtz Zentrum München, German Research, Center for Environmental Health, Neuherberg, Germany.
6
6Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.
7
7Molecular Metabolic Control, Medical Faculty, Technical University Munich, Munich, Germany.
8
8German Center for Diabetes Research (DZD), Neuherberg, Germany.
9
9Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
10
10Division for Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Abstract

There is increasing evidence that senescent cells are a driving force behind many age-related pathologies and that their selective elimination increases the life- and healthspan of mice. Senescent cells negatively affect their surrounding tissue by losing their cell specific functionality and by secreting a pro-tumorigenic and pro-inflammatory mixture of growth hormones, chemokines, cytokines and proteases, termed the senescence-associated secretory phenotype (SASP). Here we identified an extract from the plant Solidago virgaurea subsp. alpestris, which exhibited weak senolytic activity, delayed the acquisition of a senescent phenotype and induced a papillary phenotype with improved functionality in human dermal fibroblasts. When administered to stress-induced premature senescent fibroblasts, this extract changed their global mRNA expression profile and particularly reduced the expression of various SASP components, thereby ameliorating the negative influence on nearby cells. Thus, the investigated plant extract represents a promising possibility to block age-related loss of tissue functionality.

Conflict of interest statement

J.G. is co-founder and CSO of Evercyte GmbH. I.B., F.M., F.L., N.F., S.F., A.To., A.Tr. and L.W. are employees of Chanel R&T. CHANEL filed a patent for the cosmetic use of 1201 and I.L., J.G., F.G., I.B. and A.Tr. are listed as inventors.

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