Send to

Choose Destination
Front Neural Circuits. 2018 Apr 5;12:25. doi: 10.3389/fncir.2018.00025. eCollection 2018.

Neuronal Calcium Signaling in Metabolic Regulation and Adaptation to Nutrient Stress.

Author information

National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India.


All organisms can respond physiologically and behaviorally to environmental fluxes in nutrient levels. Different nutrient sensing pathways exist for specific metabolites, and their inputs ultimately define appropriate nutrient uptake and metabolic homeostasis. Nutrient sensing mechanisms at the cellular level require pathways such as insulin and target of rapamycin (TOR) signaling that integrates information from different organ systems like the fat body and the gut. Such integration is essential for coordinating growth with development. Here we review the role of a newly identified set of integrative interneurons and the role of intracellular calcium signaling within these neurons, in regulating nutrient sensing under conditions of nutrient stress. A comparison of the identified Drosophila circuit and cellular mechanisms employed in this circuit, with vertebrate systems, suggests that the identified cell signaling mechanisms may be conserved for neural circuit function related to nutrient sensing by central neurons. The ideas proposed are potentially relevant for understanding the molecular basis of metabolic disorders, because these are frequently linked to nutritional stress.


AgRP neurons; Drosophila melanogaster; glutamatergic neurons; hypothalamus; mNSC; neuronal control of metabolism

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center