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Neuron. 2018 Apr 18;98(2):256-281. doi: 10.1016/j.neuron.2018.03.040.

Genetic Dissection of Neural Circuits: A Decade of Progress.

Author information

1
Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
2
Systems Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: callaway@salk.edu.
3
Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA.

Abstract

Tremendous progress has been made since Neuron published our Primer on genetic dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical, neurophysiological, and perturbation studies have been carried out in a multitude of invertebrate and vertebrate organisms, linking neurons and circuits to behavioral functions. New methods allow systematic classification of cell types and provide genetic access to diverse neuronal types for studies of connectivity and neural coding during behavior. Here we evaluate key advances over the past decade and discuss future directions.

PMID:
29673479
PMCID:
PMC5912347
DOI:
10.1016/j.neuron.2018.03.040
[Indexed for MEDLINE]
Free PMC Article

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