Format

Send to

Choose Destination
Neural Dev. 2018 Apr 19;13(1):6. doi: 10.1186/s13064-018-0103-z.

Neural circuits driving larval locomotion in Drosophila.

Author information

1
Institute of Neuroscience, Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, OR, 97403, USA.
2
Division of Biology and Biological Engineering, California Institute of Technology, Pasedena, CA, 91125, USA.
3
Institute of Neuroscience, Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, OR, 97403, USA. cdoe@uoregon.edu.

Abstract

More than 30 years of studies into Drosophila melanogaster neurogenesis have revealed fundamental insights into our understanding of axon guidance mechanisms, neural differentiation, and early cell fate decisions. What is less understood is how a group of neurons from disparate anterior-posterior axial positions, lineages and developmental periods of neurogenesis coalesce to form a functional circuit. Using neurogenetic techniques developed in Drosophila it is now possible to study the neural substrates of behavior at single cell resolution. New mapping tools described in this review, allow researchers to chart neural connectivity to better understand how an anatomically simple organism performs complex behaviors.

KEYWORDS:

Locomotion; Locomotor circuits; Multisensory integration; Navigation; Neurodevelopment; Sensorimotor; Wave propagation

PMID:
29673388
PMCID:
PMC5907184
DOI:
10.1186/s13064-018-0103-z
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center