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Int J Mol Sci. 2018 Apr 19;19(4). pii: E1241. doi: 10.3390/ijms19041241.

HIV Vaccination: A Roadmap among Advancements and Concerns.

Author information

1
INSERM u1016, Institut Cochin, 27 Rue du Faubourg Saint Jacques, 75014 Paris, France. maria.trovato81@yahoo.it.
2
Institute of Protein Biochemistry, C.N.R., Via Pietro Castellino 111, 80131 Naples, Italy. maria.trovato81@yahoo.it.
3
Institute of Protein Biochemistry, C.N.R., Via Pietro Castellino 111, 80131 Naples, Italy. l.dapice@ibp.cnr.it.
4
Institute of Genetics and Biophysics A. Buzzati-Traverso, C.N.R., Via Pietro Castellino 111, 80131 Naples, Italy. antonella.prisco@igb.cnr.it.
5
Institute of Protein Biochemistry, C.N.R., Via Pietro Castellino 111, 80131 Naples, Italy. p.deberardinis@ibp.cnr.it.

Abstract

Since the identification of the Human Immunodeficiency Virus type 1 (HIV-1) as the etiologic agent of AIDS (Acquired Immunodeficiency Syndrome), many efforts have been made to stop the AIDS pandemic. A major success of medical research has been the development of the highly active antiretroviral therapy and its availability to an increasing number of people worldwide, with a considerable effect on survival. However, a safe and effective vaccine able to prevent and eradicate the HIV pandemic is still lacking. Clinical trials and preclinical proof-of-concept studies in nonhuman primate (NHP) models have provided insights into potential correlates of protection against the HIV-1 infection, which include broadly neutralizing antibodies (bnAbs), non-neutralizing antibodies targeting the variable loops 1 and 2 (V1V2) regions of the HIV-1 envelope (Env), polyfunctional antibody, and Env-specific T-cell responses. In this review, we provide a brief overview of different HIV-1 vaccine approaches and discuss the current understanding of the cellular and humoral correlates of HIV-1 immunity.

KEYWORDS:

HIV-1; clinical trials; immune correlates; vaccines

PMID:
29671786
PMCID:
PMC5979448
DOI:
10.3390/ijms19041241
[Indexed for MEDLINE]
Free PMC Article

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