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Future Med Chem. 2018 Apr 1;10(7):795-809. doi: 10.4155/fmc-2017-0204. Epub 2018 Apr 19.

The critical role of epigallocatechin gallate in regulating mitochondrial metabolism.

Shi W1,2, Li L1,2,3, Ding Y1,2, Yang K1,2, Chen Z1,2, Fan X2, Jiang S3, Guan Y4, Liu Z5, Xu D6, Wu L1,2.

Author information

1
College of Pharmacy, Gannan Medical University, Ganzhou, 341000 PR China.
2
Industrial Comprehensive Development & Engineering Research Center for Camellia Oleifera in Gannan Medical University, Ganzhou, 341000 PR China.
3
Department of Academic Registry, Beijing University of Chinese Medicine, Beijing, 100029 PR China.
4
Department of Orthopaedics, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI 02903, USA.
5
School of Basic Medicine, Gannan Medical University, Ganzhou 341000, PR China.
6
Department of Pharmacology, Guangdong Medical University, Dongguan, 523808 PR China.

Abstract

Epigallocatechin gallate (EGCG), one of polyphenols isolated from green tea, exhibits biology-benefiting effects with minimum severe adverse. EGCG is known to be a mitochondrion-targeting medicinal agent, regulating mitochondrial metabolism, including mitochondrial biogenesis, mitochondrial bioenergetics, and mitochondria-mediated cell cycle and apoptosis. EGCG might exhibit either antioxidative activity to prevent against oxidative stress or pro-oxidative activity to counteract cancer cells, which depends on the cellular stress situations, cell types and the concentration of EGCG. Recent research has gained positive and promising data. This review will discuss the interaction between EGCG and mitochondrion.

KEYWORDS:

EGCG; ROS; mitochondrial apoptosis; mitochondrial bioenergetics; mitochondrial biogenesis; mitochondrion; oxidative stress

PMID:
29671630
DOI:
10.4155/fmc-2017-0204
[Indexed for MEDLINE]

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