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RNA Biol. 2018;15(6):829-831. doi: 10.1080/15476286.2018.1460996. Epub 2018 May 9.

Positioning Europe for the EPITRANSCRIPTOMICS challenge.

Author information

1
a Medical University of Vienna , Department of Cell- and Developmental Biology , Vienna , Austria.
2
b UNIVERSITA DEGLI STUDI DI TRENTO , Italy.
3
c CEITEC, Masaryk University , Brno , Czech Republic.
4
d Johannes Gutenberg Universitat Mainz , Mainz , Germany.
5
e University of Cambridge , Cambridge , United Kingdom.
6
f Hospital Complex of Malaga (Virgen de la Victoria) , Malaga , Spain.
7
g Stockholm University , Sweden.
8
h IMBA - Institute of Molecular Biotechnology , Vienna , Austria.
9
i Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege , Sart Tilman , Belgium.
10
j ULB-Faculty of Medicine , Brussels , Belgium.
11
k The Cyprus Institute of Neurology & Genetics (CING) , Cyprus.
12
l University of Copenhagen , Copenhagen , Denmark.
13
m CNRS, University of Perpignan , Perpignan , France.
14
n Lorraine University -CNRS Biopole UL , Lorraine , France.
15
o Institute of Molecular Biology , Mainz , Germany.
16
p University of Thessaly , Department of Biochemistry and Biotechnology Thessaly , Greece.
17
q Biotalentum Ltd Gödöllö , Hungary.
18
r University College Cork Biochemistry Department , Cork , Ireland.
19
s Trinity College Dublin Trinity Biomedical Sciences Institute , Dublin , Ireland.
20
t Technion - Israel institute of technology , Haifa , Israel.
21
u Tel Aviv University , Tel Aviv , Israel.
22
v Center for Genomic Science of IIT@SEMM , Milano , Italy.
23
w University of Latvia , Riga , Latvia.
24
x Riga Stradins University A.Kirhensteins Institute of Microbiology , Riga , Latvia.
25
y National Blood Transfusion Service, St. Luke's Hospital , Malta.
26
z University of Malta Centre for Molecular Medicine and Biobanking Biomedical sciences , Malta.
27
aa Norwegian University of Science and Technology Department of Cancer Research and Molecular Medicine, Faculty of Medicine Norwegian , Trondheim , Norway.
28
ab Oslo University Hospital , Oslo , Norway.
29
ac International Institute of Molecular and Cell Biology in Warsaw , Poland.
30
ad Instituto Portugues de Oncologia do Porto , Porto , Portugal.
31
ae IPATIMUP , Porto , Portugal.
32
af "Victor Babes" National Institute of Pathology Bucharest , Romania.
33
ag Faculty of Biology , University o Bucharest , Bucharest , Romania.
34
ah Institute for Biological Research "Sinisa Stankovic" , Belgrade , Serbia.
35
ai Institute of Molecular Genetics and Genetic Engineering, University of Belgrade , Belgrade , Serbia.
36
aj Faculty of Pharmacy, University of Bratislava , Slovakia.
37
ak Fundacion para la Gestion de la Investigacion Biomedica de Cadiz , Cadiz , Spain.
38
al Polygene AG , Zürich , Switzerland.
39
am Gebze Technical University , Gebze , Turkey.
40
an Istanbul Medipol University , Istanbul , Turkey.
41
ao University of Dundee Centre for Gene Regulation and Expression School of Life Sciences , Dundee , United Kingdom.
42
ap Universite Libre de Bruxelles , Gosselies , Belgium.
43
aq Institut de Genomique Fonctionnelle , Montpellier , France.
44
ar Institut de Biologie Paris Seine - Pierre et Marie Curie University Institut de Biologie Paris , Paris , France.
45
as German Cancer Research Center , Heidelberg , Germany.
46
at University of Kassel , Kassel , Germany.
47
au Weizmann Institute of Science , Rehovot , Israel.
48
av Institute for Advanced Bioscience , Grenoble , France.
49
aw Fundacion IMDEA Alimentacion Ctra . de Canto Blanco, Madrid , Spain.
50
ax Germans Trias i Pujol Research Institute , Barcelona , Spain.
51
ay University of Edinburgh MRC Centre for Regenerative Medicine , Edinburgh , United Kingdom.
52
az The Francis Crick Institute , London , United Kingdom.
53
ba University of Nottingham School of Biosceinces , Nottingham , United Kingdom.

Abstract

The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.

KEYWORDS:

European funding; database of Modification; detection of RNA modification; epitranscriptomics; model systems

PMID:
29671387
PMCID:
PMC6152430
DOI:
10.1080/15476286.2018.1460996
[Indexed for MEDLINE]
Free PMC Article

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