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Metab Brain Dis. 2018 Aug;33(4):1255-1260. doi: 10.1007/s11011-018-0240-4. Epub 2018 Apr 18.

The Radish, Raphanus sativus L. Var. caudatus reduces anxiety-like behavior in mice.

Author information

1
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
2
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan. ishratyounas@gmail.com.
3
Department of Pharmacology, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan. ishratyounas@gmail.com.

Abstract

Inclusion of vegetables in the diet not only provides dietary fiber, vitamins, minerals, trace elements but also significantly reduces the risk of several diseases. Raphanus sativus L. Var. caudatus belongs to the family Brassicaceae are pods of Radish, and are commonly known as Mungra or Sungra in Pakistan and India. The English name for this species is Rat-tailed radish. This variety of radish is unique, less familiar to the population, and not commonly used as a food source. Furthermore there have been very few studies that report on the potential antioxidant and anti-cancer capabilities of this radish. The present study was designed to evaluate anxiolytic potential of Raphanus caudatus in mice using different behavioral paradigms. The ethanol extract of the plant was evaluated at three different doses i.e. 250, 500 and 1000 mg/kg. The extract at doses of 250 and 500 mg/kg produced a significant (p < 0.05) reduction of anxiety-like behavior in mice and results are comparable to standard anxiolytic drug diazepam.

KEYWORDS:

Anxiety; Ethanol extract; Mice; Raphanus caudatus

PMID:
29671209
DOI:
10.1007/s11011-018-0240-4
[Indexed for MEDLINE]

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