Format

Send to

Choose Destination
Biomed Res Int. 2018 Jan 24;2018:4076430. doi: 10.1155/2018/4076430. eCollection 2018.

Effects of Withania somnifera on Reproductive System: A Systematic Review of the Available Evidence.

Author information

1
Department of Iranian Traditional Medicine, School of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
2
Department of Urology, Emam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
3
Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
4
Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
5
Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
6
Department of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
7
Department of Urology, Sina Hospital, Tabriz University of Medical Science, Tabriz, Iran.

Abstract

Introduction:

Withania somnifera (WS) also known as ashwagandha is a well-known medicinal plant used in traditional medicine in many countries for infertility treatment. The present study was aimed at systemically reviewing therapeutic effects of WS on the reproductive system.

Methods:

This systematic review study was designed in 2016. Required data were obtained from PubMed, Scopus, Google Scholar, Cochrane Library, Science Direct, Web of Knowledge, Web of Science, and manual search of articles, grey literature, reference checking, and expert contact.

Results:

WS was found to improve reproductive system function by many ways. WS extract decreased infertility among male subjects, due to the enhancement in semen quality which is proposed due to the enhanced enzymatic activity in seminal plasma and decreasing oxidative stress. Also, WS extract improved luteinizing hormone and follicular stimulating hormone balance leading to folliculogenesis and increased gonadal weight, although some animal studies had concluded that WS had reversible spermicidal and infertilizing effects in male subjects.

Conclusion:

WS was found to enhance spermatogenesis and sperm related indices in male and sexual behaviors in female. But, according to some available evidences for spermicidal features, further studies should focus on the extract preparation method and also dosage used in their study protocols.

PMID:
29670898
PMCID:
PMC5833251
DOI:
10.1155/2018/4076430
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Limited Icon for PubMed Central
Loading ...
Support Center