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Clin Cosmet Investig Dermatol. 2018 Apr 6;11:141-148. doi: 10.2147/CCID.S158428. eCollection 2018.

The efficacy of a pseudo-ceramide and eucalyptus extract containing lotion on dry scalp skin.

Author information

Skin Care Product Research, Kao Corporation, Tokyo, Japan.
Ebisu Skin Research Center, Inforward, Inc., Tokyo, Japan.
Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan.



Dry and scaly conditions on the scalp are often observed in patients with atopic dermatitis, seborrheic dermatitis and/or pityriasis capitis. Those scalp lesions often exhibit low barrier function and reduced ceramide levels. Therefore, a clinical study was conducted to evaluate the efficacy of topical application of a pseudo-ceramide and eucalyptus extract-containing lotion on the scalps of patients with skin diseases.


Thirty-four subjects participated in this study (atopic dermatitis: 19 subjects; seborrheic dermatitis: 6 subjects; pityriasis capitis: 9 subjects). After 4 weeks of daily treatment with a pseudo-ceramide and eucalyptus extract-containing lotion, the skin symptoms had significantly improved in all patients with those skin diseases.


Skin dryness, scaling, and erythema were significantly improved by treatment with the lotion. The moisture-retention ability of the scalp was significantly increased and itchiness, evaluated using a visual analog scale, decreased significantly. Accompanying those improvements was a significant improvement in the quality of life of the subjects, evaluated by the Skindex-16®.


From these results, we conclude that this pseudo-ceramide and eucalyptus extract-containing lotion effectively improved the dry and scaly conditions of the scalp as well as the quality of life of subjects with atopic dermatitis, seborrheic dermatitis, or pityriasis capitis.


formulation; inflammation; moisturization; scalp lotion; sensitive skin; skin care

Conflict of interest statement

Disclosure Akihiko Takahashi, Xuanhe Ning, Takahiro Nishizaka, Kazuhiro Kaizu, Masahiro Miyaki, Yutaka Takagi, and Hotaka Yamamuro are employees of the Kao Corporation. Chiaki Ishizaki is an employee of Inforward Inc. Makoto Kawashima received an honorarium from Kao Corporation for supervising this study. The authors report no other conflicts of interest in this work.

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